The use of gonadotropin in bodybuilding and during hormone replacement therapy 

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Modern “civilian” medicine more and more often adopts the achievements of gerontology – a science whose goal is the fight against old age and the search for “medicines” to slow down the aging process.

But not only Aesculapius in white coats, but also bodybuilders of all stripes are interested in the problems of rejuvenating pre-retention human organisms, because drugs used by doctors to maintain the health of their patients are quite successfully used in various sports disciplines, including in iron sport.

Today we will consider one of the most popular medicines, which is not an anabolic steroid, while it is very in demand, both among pensioners and pitching.

Human chorionic gonadotropin (HCG) is a polypeptide hormone that begins to be produced after fertilization of the egg and is a marker for the development of pregnancy.

It is a gonadotropic hormone, acting as a luteinizing hormone and partially follicle-stimulating.

It consists of two subunits: alpha and beta. If the α-subunit of the chorionic hormone is completely comparable to LH, FSH and TSH, then the β-subunit of hCG is unique to this hormone and distinguishes it from other gonadotropins.

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❗ It is worth noting that the thyrotropic activity of hCG is minimal and the drug cannot be considered as a means to reduce weight.

To maintain a healthy hormonal background in obese people, it is better to resort to antiestrogens (clomiphene and toremifene citrates) in the process of losing weight on a low-calorie diet.

✅ Injections can be done either intramuscularly or subcutaneously (higher bioavailability).

✅ For the analysis of performance should resort to the analysis of the free B-subunit. Pharmacy pregnancy tests, by the way, are based on the determination of hCG in the urine.

❗ In men, an increase in hCG above 5 mU / ml in the blood is possible either against the background of exogenous administration, or in the presence of cancer.

✳️ HCG by men is used to combat azoospermia and oligospermia as a means to improve spermatogenesis; possible use against the background of primary hypogonadism (in violation of the hypothalamic-pituitary axis of regulation of secretion of sex hormones).

✳️ In the field of bodybuilding – it is used to achieve fertility and preserve the size and effectiveness of testicles on the course of anabolic steroids, to avoid their atrophy, as well as to increase the secretion of endogenous testosterone.

It is worth noting that in professional sports, taking hCG will give you a positive doping test.

✳️ On long courses of AAS, the hypothalamus stops the production of gonadotropin releasing hormone and the higher the steroid dosage on the course, the faster the production of GnRH slows down and, as a result, the pituitary gland stops the production of luteinizing hormone. Without LH, the testicles “fall asleep” and stop the production of testosterone.

✅ There are several regimens for taking chorionic gonadotropin on an AAS course. The safest is considered to be weekly dosages of 1000-1500 IU in size divided by 1-2 injections. The scheme involves taking the drug from the 3rd week of the course until its completion (access to post-cycle therapy).

✅ There is a second option, when hCG is placed once a quarter or even every six months, for three weeks, but already in dosages of 1500 IU once every 4 days. This option is more suitable for athletes who are on long courses, most of them because of a simpler administration.

✅ The protocols for using hCG after the steroid cycle to accelerate further recovery on antiestrogens involve injections of 1,500– 2,500 IU every 3-4 days for two to three weeks.

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❗ I note that taking HCG at courses of more than 8 weeks is considered rational, for shorter periods the probability of irreversible atrophy of the testicles is extremely small.

✅ Chorionic gonadotropin can also be used by athletes to maintain a normal hormonal profile in the process of removing the remnants of the “tails” of various ether chains of anabolic steroids before going to PCT.

❗ Due to the effect of chorionic gonadotropin on testosterone levels, the use of the drug will increase blood levels of estradiol and dihydrotestosterone. It is worth considering this when selecting dosages of aromatase inhibitors on the course.

HCG is sometimes used as a drug for hormone replacement therapy, but this solution has several disadvantages:

  • Firstly, hCG injections for an even background of hormones must be done every 3-4 days.
  • Secondly, there are problems with bursts of estradiol due to gonadal aromatization, which are difficult to stop by aromatase inhibitors.
  • Thirdly, with prolonged use of hCG, testicular tolerance to gonadotropins may occur.

❗ Dosages of 5000 IU at a time or the use of high dosages of hCG for a long period of time can lead to desensitization of the testicles (reduce their sensitivity to LH)!

Studies by the well-known Dr. Michael Scully have confirmed that desensitization of the testes does not occur at doses of human chorionic gonadotropin less than 1500 IU per week.

  • The weekly hormone replacement dosage of luteinizing hormone is considered to be ~ 1500 IU.
  • After a single injection of 1000-1500 IU, testosterone will remain in the upper limits of the first 4 days, with a subsequent decrease to the end of the week below the reference values.
  •  Weekly dosages of 1000 IU or less, most likely, will not cause a complete shutdown of the hypothalamic-pituitary function.

 The use of hCG at a dosage of more than 1,500 IU per week will reduce the production of your own gonadotropins and the higher the dosage, the faster this process will proceed.